Sato, D.; Fujiwara, K.; Kondo, Y.; Akiba, U.; Tokiwano, T., An approach to a 2-hydroxy-3-phenyldibenzofuran skeleton based on Rh(PPh3)3Cl-catalyzed [2+2+2] cycloaddition between a 1-ethynyl-2-(ethynyloxy)benzene and an (alkoxyethynyl)benzene. Heterocycles 2020, 101 (2), 417-422. doi:10.3987/COM-19-S(F)34
Oyama, M.; Tokiwano, T.; Ota, H.; Mizuno, K.; Oh, K.; Kawaii, S.; Yoshizawa, Y., β-Sitosterol Oxides From the Dried Stem of Salix gilgiana Inhibit the Proliferation of HL-60 Leukemic Cells. Current Bioactive Compounds 2020, 16 (3), 329-334. doi:10.2174/1573407214666181026110106
Hashizume, K.; Ito, T.; Shirato, K.; Amano, N.; Tokiwano, T.; Ohno, T.; Shindo, S.; Watanabe, S.; Okuda, M., Factors affecting levels of ferulic acid, ethyl ferulate and taste-active pyroglutamyl peptides in sake. Journal of Bioscience and Bioengineering 2020, 129 (3), 322-326. doi:10.1016/j.jbiosc.2019.09.021
Fujiwara, K.; Itagaki, T.; Kondo, Y.; Akiba, U.; Tokiwano, T., Total synthesis of selaginellin S. Tetrahedron Letters 2020, 61 (25). doi:10.1016/j.tetlet.2020.152031
Hashizume, K.; Ito, T.; Nagae, Y.; Tokiwano, T., Quantitation and sensory properties of three newly identified pyroglutamyl oligopeptides in sake. Bioscience, Biotechnology and Biochemistry 2019, 83 (2), 357-364. doi:10.1080/09168451.2018.1530095
Fujiwara, K.; Motousu, R.; Sato, D.; Kondo, Y.; Akiba, U.; Suzuki, T.; Tokiwano, T., Total synthesis of kehokorins A and B. Tetrahedron Letters 2019, 60 (18), 1299-1301. doi:10.1016/j.tetlet.2019.04.011
Shinde, S. S.; Minami, A.; Chen, Z.; Tokiwano, T.; Toyomasu, T.; Kato, N.; Sassa, T.; Oikawa, H., Cyclization mechanism of phomopsene synthase: Mass spectrometry based analysis of various site-specifically labeled terpenes. Journal of Antibiotics 2017, 70 (5), 632-638. doi:10.1038/ja.2017.27
Oyama, M.; Tokiwano, T.; Kawaii, S.; Yoshida, Y.; Mizuno, K.; Oh, K.; Yoshizawa, Y., Protodioscin, isolated from the rhizome of dioscorea tokoro collected in northern Japan is the major antiproliferative compound to HL-60 leukemic cells. Current Bioactive Compounds 2017, 13 (2), 170-174. doi:10.2174/1573407213666170113123428
Mizuno, K.; Tokiwano, T.; Yoshizawa, Y., Gene expression analysis of enzymes of the carotenoid biosynthesis pathway involved in β-cryptoxanthin accumulation in wild raspberry, Rubus palmatus. Biochemical and Biophysical Research Communications 2017, 484 (4), 845-849. doi:10.1016/j.bbrc.2017.01.186
Suzuki, N.; Ito, T.; Hiroshima, K.; Tokiwano, T.; Hashizume, K., Formation of ethyl ferulate from feruloylated oligosaccharide by transesterification of rice koji enzyme under sake mash conditions. Journal of Bioscience and Bioengineering 2016, 121 (3), 281-285. doi:10.1016/j.jbiosc.2015.06.015
Takahashi, S.; Gotoh, T.; Hata, K.; Tokiwano, T.; Yoshizawa, Y.; Hiwatashi, K.; Ogasawara, H.; Hori, K., Renin inhibitors in foodstuffs: Structure-function relationship. Journal of Biological Macromolecules 2014, 14 (2), 71-84. doi:10.14533/jbm.14.71
Mizuno, K.; Matsuzaki, M.; Kanazawa, S.; Tokiwano, T.; Yoshizawa, Y.; Kato, M., Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B′ methyltransferase family in Coffea arabica. Biochemical and Biophysical Research Communications 2014, 452 (4), 1060-1066. doi:10.1016/j.bbrc.2014.09.043
Kawaii, S.; Ikuina, T.; Hikima, T.; Tokiwano, T.; Yoshizawa, Y., Relationship between structure and antiproliferative activity of polymethoxyflavones towards HL60 cells. Anticancer Research 2012, 32 (12), 5239-5244.
Kawaii, S.; Endo, K.; Tokiwano, T.; Yoshizawa, Y., Relationship between structure and antiproliferative activity of 1-azaflavanones. Anticancer Research 2012, 32 (7), 2819-2825.
Hashizume, K.; Ito, T.; Shimohashi, M.; Kokita, A.; Tokiwano, T.; Okuda, M., Taste-guided fractionation and instrumental analysis of hydrophobic compounds in sake. Bioscience, Biotechnology and Biochemistry 2012, 76 (7), 1291-1295. doi:10.1271/bbb.120046
Takahashi, S.; Tokiwano, T.; Hata, K.; Hokari, M.; Yoshizawa, Y.; Gotoh, T., Isolation and identification of human ren in inhibitor from Aratia cordata (Udo). Journal of Biological Macromolecules 2011, 11 (3), 83-89.
Takahashi, S.; Tokiwano, T.; Hata, K.; Kodama, I.; Hokari, M.; Suzuki, N.; Yoshizawa, Y.; Gotoh, T., The occurrence of renin inhibitor in rice: Isolation, identification, and structure-function relationship. Bioscience, Biotechnology and Biochemistry 2010, 74 (8), 1713-1715. doi:10.1271/bbb.100233
Matsuura, Y.; Shichijo, Y.; Minami, A.; Migita, A.; Oguri, H.; Watanabe, M.; Tokiwano, T.; Watanabe, K.; Oikawa, H., Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A. Organic Letters 2010, 12 (10), 2226-2229. doi:10.1021/ol100541e
Kasahara, K.; Miyamoto, T.; Fujimoto, T.; Oguri, H.; Tokiwano, T.; Oikawa, H.; Ebizuka, Y.; Fujii, I., Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani. ChemBioChem 2010, 11 (9), 1245-1252. doi:10.1002/cbic.201000173
Tokiwano, T.; Satoh, H.; Obara, T.; Hirota, H.; Yoshizawa, Y.; Yamamoto, Y., A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta. Bioscience, Biotechnology and Biochemistry 2009, 73 (11), 2525-2527. doi:10.1271/bbb.90419
Migita, A.; Watanabe, M.; Hirose, Y.; Watanabe, K.; Tokiwano, T.; Kinashi, H.; Oikawa, H., Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Bioscience, Biotechnology and Biochemistry 2009, 73 (1), 169-176. doi:10.1271/bbb.80631
Tokiwano, T.; Watanabe, H.; Seo, T.; Oikawa, H., Unprecedented biological cyclopropanation in the biosynthesis of FR-900848. Chemical Communications 2008, (45), 6016-6018. doi:10.1039/b809610d
Shichijo, Y.; Migita, A.; Oguri, H.; Watanabe, M.; Tokiwano, T.; Watanabe, K.; Oikawa, H., Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: Direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis. Journal of the American Chemical Society 2008, 130 (37), 12230-12231. doi:10.1021/ja8040543
Migita, A.; Shichijo, Y.; Oguri, H.; Watanabe, M.; Tokiwano, T.; Oikawa, H., Stereo-controlled synthesis of prelasalocid, a key precursor proposed in the biosynthesis of polyether antibiotic lasalocid A. Tetrahedron Letters 2008, 49 (6), 1021-1025. doi:10.1016/j.tetlet.2007.12.003
Tsukagoshi, T.; Tokiwano, T.; Oikawa, H., Studies on the later stage of the biosynthesis of pleuromutilin. Bioscience, Biotechnology and Biochemistry 2007, 71 (12), 3116-3121. doi:10.1271/bbb.70547
Watanabe, H.; Tokiwano, T.; Oikawa, H., Biosynthetic study of FR-900848: Unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA. Tetrahedron Letters 2006, 47 (9), 1399-1402. doi:10.1016/j.tetlet.2005.12.091
Watanabe, H.; Tokiwano, T.; Oikawa, H., Biosynthetic study of FR-900848: Origin of the aminodeoxynucleoside part. Journal of Antibiotics 2006, 59 (9), 607-610. doi:10.1038/ja.2006.82
Tokiwano, T.; Endo, T.; Tsukagoshi, T.; Goto, H.; Fukushi, E.; Oikawa, H., Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene. Organic and Biomolecular Chemistry 2005, 3 (15), 2713-2722. doi:10.1039/b506411b
Tokiwano, T.; Fukushi, E.; Endo, T.; Oikawa, H., Biosynthesis of phomactins: Common intermediate phomactatriene and taxadiene. Chemical Communications 2004, 4 (11), 1324-1325. doi:10.1039/b401377h
Oikawa, H.; Tokiwano, T., Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products. Natural Product Reports 2004, 21 (3), 321-352. doi:10.1039/b305068h
Fujino, A.; Ose, T.; Yao, M.; Tokiwano, T.; Honma, M.; Watanabe, N.; Tanaka, I., Structural and enzymatic properties of 1-aminocyclopropane-1-carboxylate deaminase homologue from Pyrococcus horikoshii. Journal of Molecular Biology 2004, 341 (4), 999-1013. doi:10.1016/j.jmb.2004.06.062
Fueki, S.; Tokiwano, T.; Toshima, H.; Oikawa, H., Biosynthesis of indole diterpenes, emindole, and paxilline: Involvement of a common intermediate. Organic Letters 2004, 6 (16), 2697-2700. doi:10.1021/ol049115o
Fujiwara, K.; Morishita, H.; Tokiwano, T.; Murai, A., Benzyloxymethyl group as a convertible internal ligand for La(OTf)3-catalyzed 7-endo ring-opening of hydroxy epoxide. Heterocycles 2001, 54 (1), 109-110. doi:10.3987/com-00-s(i)77
Tokiwano, T.; Fujiwara, K.; Murai, A., Effect of molecular sieves and methanol on the endo-selectivity in La(OTf)3-catalyzed cyclization of 5-hydroxy-2-methoxymethyl-1,2-epoxide system. Chemistry Letters 2000, (3), 272-273. doi:10.1246/cl.2000.272
Tokiwano, T.; Fujiwara, K.; Murai, A., Biomimetic construction of fused tricyclic ether by cascaded endo- cyclization of the hydroxy triepoxide. Synlett 2000, (3), 335-338.
Fujiwara, K.; Amano, A.; Tokiwano, T.; Murai, A., Novel oxepane formation by TiCl4-catalyzed nucleophilic cleavage of 1- alkoxymethyl-6,8-dioxabicyclo[3.2.1]octanes. Tetrahedron 2000, 56 (8), 1065-1080. doi:10.1016/S0040-4020(00)00009-0
Fujiwara, K.; Hayashi, N.; Tokiwano, T.; Murai, A., Chemical realization of the biogenetic pathways proposed for the fused- polycyclic ethers of marine origins. Heterocycles 1999, 50 (1), 561-593. doi:10.3987/rev-98-sr(h)4
Fujiwara, K.; Mishima, H.; Amano, A.; Tokiwano, T.; Murai, A., La(OTf)3-catalyzed 7-endo and 8-endo selective cyclizations of hydroxy epoxides. Tetrahedron Letters 1998, 39 (5-6), 393-396. doi:10.1016/S0040-4039(97)10557-3
Fujiwara, K.; Amano, A.; Tokiwano, T.; Murai, A., Novel oxepane formation by reductive cleavage of 1-methoxymethyl-6,8-dioxabicyclo[3.2.1]octanes. Heterocycles 1998, 47 (1), 111-112. doi:10.3987/com-97-s(n)37
Fujiwara, K.; Tokiwano, T.; Murai, A., La(otf)3-catalyzed 6-endo epoxide opening of 4, 5-epoxy-4-methoxymethyl-1-hexanols. Tetrahedron Letters 1995, 36 (44), 8063-8066. doi:10.1016/0040-4039(95)01709-Q